Objective. Evaluate the patterns of e-cigarette use and their association with smoking behavior. Materials and Methods. We analyzed data from a population-based representative cohort of adult smokers who participated in the International Tobacco Control Policy Evaluation Sur¬veys in Mexico. The analytic sample (n=760) was restricted to participants who were followed up from wave 6 (2012) to wave 7 (2014-2015). GEE models regressed e-cigarette use at follow-up and changes in cigarettes per day (CPD) between waves, on baseline sociodemographic variables, smoking status (daily, non-daily, quit), e-cigarette trial, and quit intentions. Results. Smokers who were younger, had a higher income, and had tried e-cigarettes at baseline were more likely to be current e-cigarette users at follow-up. E-cigarette use at follow-up was not associated with a change in CPD over time. Conclusions. E-cigarette use does not appear to have promoted smoking cessation or reduction in this sample of Mexican smokers.